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All Journal IJCCS (Indonesian Journal of Computing and Cybernetics Systems) Seminar Nasional Aplikasi Teknologi Informasi (SNATI) Jurnal Ilmiah Teknik Elektro Komputer dan Informatika (JITEKI) Indonesia Symposium on Computing Indonesian Journal on Computing (Indo-JC) IJoICT (International Journal on Information and Communication Technology) JOIN (Jurnal Online Informatika) Jurnal Teknologi dan Sistem Komputer Sinkron : Jurnal dan Penelitian Teknik Informatika Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) JURNAL MEDIA INFORMATIKA BUDIDARMA Building of Informatics, Technology and Science Journal of Computer System and Informatics (JoSYC) Jurnal Teknik Informatika (JUTIF) JINAV: Journal of Information and Visualization eProceedings of Engineering
Erwin Budi Setiawan
Telkom University
Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Engineering Industrial & Manufacturing Engineering Library & Information Science Mathematics

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Journal : JOIN (Jurnal Online Informatika)

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Implementation of Ant Colony Optimization – Artificial Neural Network in Predicting the Activity of Indenopyrazole Derivative as Anti-Cancer Agent Isman Kurniawan; Nabilla Kamil; Annisa Aditsania; Erwin Budi Setiawan
JOIN (Jurnal Online Informatika) Vol 8 No 1 (2023)
Publisher : Department of Informatics, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/join.v8i1.1055

Abstract

Cancer is a disease induced by the abnormal growth of cells in body tissues. This disease is commonly treated by chemotherapy. However, at first, cancer cells can respond to the activity of chemotherapy over time, but over time, resistance to cancer cells appears. Therefore, it is required to develop new anti-cancer drugs. Indenopyrazole and its derivative have been investigated to be a potential drug to treat cancer. This study aims to predict indenopyrazole derivative compounds as anti-cancer drugs by using Ant Colony Optimization (ACO) and Artificial Neural Network (ANN) methods. We used 93 compounds of indenopyrazole derivative with a total of 1876 descriptors. Then, the descriptors were reduced by using the Pearson Correlation Coefficient (PCC) and followed by the ACO algorithm to get the most relevant features. We found that the best number of descriptors obtained from ACO is ten descriptors. The ANN prediction model was developed with three architectures, which are different in hidden layer number, i.e., 1, 2, and 3 hidden layers. Based on the results, we found that the model with three hidden layers gives the best performance, with the value of the R2 test, R2 train, and Q2 train being 0.8822, 0.8495, and 0.8472, respectively.
Co-Authors Aditya Mahendra Zakaria Agung Toto Wibowo Ahmad Zahri Ruhban Adam Aji Reksanegara Alvi Rahmy Royyan Anang Furkon RIfai Ananta Ihza Ramadhan Anindika Riska Intan Fauzy Annisa Aditsania Annisa Aditsania Annisa Cahya Anggraeni Annisa Cahya Anggraeni Annisa Rahmaniar Dwi Pratiwi Arie Ardiyanti Arki Rifazka Athirah Rifdha Aryani Azrina Fazira Ansshory Bagas Teguh Imani Billy Anthony Christian Martani Brenda Irena Brigita Tenggehi Crisanadenta Wintang Kencana Damarsari Cahyo Wilogo Daniar Dwi Pratiwi Daniar Dwi Pratiwi Dede Tarwidi Dedy Handriyadi Dery Anjas Ramadhan Dhinta Darmantoro Diaz Tiyasya Putra Dion Pratama Putra Diyas Puspandari Faidh Ilzam Nur Haq Fathurahman Alhikmah Fathurahman Alhikmah Febiana Anistya Feby Ali Dzuhri Fhina Nhita Fhina Nhita Fida Nurmala Nugraha Ghani Kamil Ghina Dwi Salsabila Gita Safitri Grace Yohana Grace Yohana Hanif Reangga Alhakiem Helmi Sunjaya Ramadhan Hildan Fawwaz Naufal Hilman Bayu Aji Husnul Khotimah Farid I Gusti Ayu Putu Sintha Deviya Yuliani I Kadek Candradinata Ilyana Fadhilah Iqbal, Bayu Muhammad Irma Palupi Isabella Vichita Kacaribu Isep Mumu Mubaroq Isman Kurniawan Kartika Prameswari Kemas Muslim Lhaksmana, Kemas Muslim Kevin Usmayadhy Wijaya Luthfi Firmansah M. Arif Bijaksana Mahmud Imrona Mansel Lorenzo Nugraha Marissa Aflah Syahran Marissa Aflah Syahran Maulina Gustiani Tambunan Mela Mai Anggraini Moh Adi Ikfini M Muhammad Afif Raihan Muhammad Faiq Ardyanto Putro Muhammad Khiyarus Syiam Muhammad Kiko Aulia Reiki Muhammad Noer Ibnu Sina Muhammad Nur Ilyas Muhammad Shiba Kabul Muhammad Tsaqif Muhadzdzib Ramadhan Nabilla Kamil Naufal Adi Nugroho Nisa Maulia Azahra Nur Ihsan Putra Munggaran Rafi Anandita Wicaksono Raisa Sianipar Rakhmat Rifaldy Rayhan Rahmanda Refka Muhammad Furqon Rendo Zenico Ridho Maulana Cahyudi Rizki Annas Sholehat Rizki Tri Setiawan Roji Ellandi Sari Ernawati Saut Sihol Ritonga Septian Nugraha Kudrat Septian Nugraha Kudrat Shakina Rizkia Siti Inayah Putri Sri Suryani Sri Suryani Sukmawati Dwi Lestari Wida Sofiya Windy Ramadhanti Yoan Maria Vianny Yuliant Sibaroni ZK Abdurahman Baizal